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Kunkl M, Frascolla S, Amormino C, Volpe E, Tuosto L

[DOI] [PubMed] [Google Scholar] 71.Folkman J., Klagsbrun M

Under physiological conditions, more than 98% of the total GSH pool exists in the reduced form, thereby shaping cellular redox potential and influencing proliferation, differentiation, and cell death 5 .Although the GSH/GSSG ratio has long been regarded as an indicator of cellular redox status, recent live-cell studies using genetically encoded redox sensors indicate that increases in GSSG are typically transient and compartmentalized rather than sustained intracellular accumulations 6,7

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Previous studies have elucidated the role of melatonin in improving animal reproductive performance, and this factor can potentially improve human-assisted reproduction in the future